"Taking a caffeine break can help the body become more sensitive to caffeine's effects." "People can reduce their tolerance to caffeine by tapering down their use of caffeine," says Morgyn Clair, a registered dietitian nutritionist. If you are no longer affected by caffeine, try taking a break. If you're no longer experiencing the stimulating effects of caffeine at that limit, you may have built too high a tolerance, as drinking more than this can cause negative effects like headaches or insomnia. The recommended maximum dosage of caffeine is 400 mg per day, which is about four cups of coffee. As a result, the caffeine needed to have the same effect you've experienced before increases. When you continue to consume caffeine at a higher quantity or frequency, the body becomes less sensitive to it. You may also not feel a buzz from your morning cup of coffee because you've built up a tolerance. Caffeine may not affect you because you've built a tolerance Which form you have depends on your genetics.Ģ. However, there are two forms of CYP1A2, one of which will metabolize caffeine faster than the other, meaning you feel less of the stimulant's effects. An enzyme in the liver called CYP1A2 is responsible for 95% of caffeine metabolization. "Genetics can play a factor in caffeine sensitivity because genetics determines how effectively the body's adenosine receptors can bind to caffeine molecules," Jenna Liphart Rhoads, PhD, a registered nurse and nurse educator at Nurse Together.Īdditionally, how quickly you feel caffeine's effects and for how long depends on your genetics. This action blocks adenosine from reaching those receptors thereby inhibiting sleepiness. Once there, they bind to receptors normally paired with adenosine, a neurotransmitter that encourages sleep. Then, caffeine molecules quickly move to the brain.
What the research says: In a 2011 study, researchers found that about 10% of people carry a gene that makes them hyposensitive to caffeine, allowing for a high caffeine intake while experiencing little to no effect.Īfter ingesting caffeine it takes about 45 minutes for the body to absorb it. Your genetics may be to blame if you can't feel caffeine's stimulating effects.
Caffeine may not affect you due to your genetics
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